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Mfuwe is the main settlement of South Luangwa National Park in the Eastern Province of Zambia, serving the tourism industry and wildlife conservation in the Luangwa Valley. It is located about 100 km (62 mi) west-north-west of Chipata.
Mfuwe has an airport with a 2.15 km (1.34 mi) surfaced runway capable of taking regional international flights.
This village holds the record of the highest temperature ever recorded in Zambia with 42.8 °C (109.0 °F) set on 26 October 2011.